Peptidylglycine alpha amidating
Also Cp immunoreactive protein levels fall following dietary copper deficiency perhaps due to faster turnover of apo-Cp.
Cp, an alpha-2 globulin, is an acute phase protein that is highly expressed during inflammation, which can be a common confounding variable using Cp to assess copper status.
There is no widely accepted biochemical marker for evaluation of human copper status (Milne, 1994; Failla et al., 2001).
Furthermore, pregnancy and lactation could have an impact on currently used markers.
Even when dietary copper is limiting, liver is fully capable of synthesizing and secreting Cp protein into the plasma after it is fully glycosylated (Holtzman and Gaumnitz, 1970; Gitlin et al., 1992).
However, following dietary copper restriction plasma Cp activity is reduced due to lack of the cofactor copper.
Although adults consume approximately the recommended intake of copper daily, pregnant and lactating women, depending on which survey is evaluated, tend not to consume the extra 100–400 µg of copper to meet recommendations (Trumbo et al., 2001).
Both cuproenzymes changed during neonatal development and when dietary copper was limiting.Furthermore Cp is induced by estrogen, thus activity of Cp is influenced by pregnancy and lactation.